The season will open with a home game against the Chicago State Cougars on November 3 at Wintrust Arena.
DePaul will conclude the season at Wintrust Arena on March 7, facing the Butler Bulldogs.
The Blue Demons are set to play 30 regular-season games, including 18 at home and 12 either away or at neutral venues.
Some games may change due to unforeseen mid-season circumstances.
Full DePaul Blue Demons Schedule for the 2025-2026 College Basketball Season
| Date | Time | Opponent | Venue |
|---|---|---|---|
| Nov. 3 | 7 p.m. | Chicago State Cougars | Wintrust Arena |
| Nov. 7 | 7 p.m. | Stonehill Skyhawks | Wintrust Arena |
| Nov. 11 | 7 p.m. | Buffalo Bulls | Wintrust Arena |
| Nov. 14 | 7:30 p.m. | Northwestern Wildcats | Wintrust Arena |
| Nov. 18 | 7 p.m. | Gardner–Webb Runnin' Bulldogs | Wintrust Arena |
| Nov. 23 | 5 p.m. | Detroit Mercy Titans | Wintrust Arena |
| Nov. 28 | 7 p.m. | Georgia Tech Yellow Jackets | |
| Dec. 6 | 8 p.m. | Arkansas-Pine Bluff Golden Lions | Wintrust Arena |
| Dec. 9 | 7 p.m. | Morgan State Bears | Wintrust Arena |
| Dec. 13 | 11 a.m. | Wichita State Shockers | Charles Koch Arena |
| Dec. 16 | 6 p.m. | St. John's Red Storm | Carnesecca Arena |
| Dec. 21 | 3:30 p.m. | UConn Huskies | Wintrust Arena |
| Dec. 31 | 5 p.m. | Villanova Wildcats | Finneran Pavilion |
| Jan. 3 | 1 p.m. | Xavier Musketeers | Wintrust Arena |
| Jan. 6 | 7 p.m. | Georgetown Hoyas | Wintrust Arena |
| Jan. 10 | 12:30 p.m. | UConn Huskies | Harry A. Gampel Pavilion |
| Jan. 16 | 7:30 p.m. | Marquette Golden Eagles | Wintrust Arena |
| Jan. 20 | 6:30 p.m. | Butler Bulldogs | Hinkle Fieldhouse |
| Jan. 24 | 4 p.m. | Seton Hall Pirates | Wintrust Arena |
| Jan. 28 | 7:30 p.m. | Georgetown Hoyas | Capital One Arena |
| Jan. 31 | 12 p.m. | Xavier Musketeers | Cintas Center |
| Feb. 3 | 7 p.m. | St. John's Red Storm | Wintrust Arena |
| Feb. 7 | 3 p.m. | Providence Friars | Amica Mutual Pavilion |
| Feb. 11 | 8 p.m. | Creighton Bluejays | Wintrust Arena |
| Feb. 18 | 8 p.m. | Seton Hall Pirates | Prudential Center |
| Feb. 21 | 7 p.m. | Providence Friars | Wintrust Arena |
| Feb. 25 | 8 p.m. | Creighton Bluejays | CHI Health Center |
| March 1 | 3 p.m. | Marquette Golden Eagles | Fiserv Forum |
| March 4 | 7 p.m. | Villanova Wildcats | Wintrust Arena |
| March 7 | 11 a.m. | Butler Bulldogs | Wintrust Arena |
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